InnateDB Protein
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IDBP-175791.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Olig2
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Protein Name
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oligodendrocyte transcription factor 2
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Synonyms
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AI604895; Bhlhb1; bHLHe19; Olg-2; Oligo2; RK17;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000036797
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InnateDB Gene
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IDBG-175789 (Olig2)
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Protein Structure
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Function |
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. {ECO:0000269PubMed:11955448, ECO:0000269PubMed:12121626}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.
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Disease Associations |
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Tissue Specificity |
Expressed specifically in the brain. {ECO:0000269PubMed:11091082}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0003705
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RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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GO:0042803
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protein homodimerization activity
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GO:0046983
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protein dimerization activity
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GO:0071837
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HMG box domain binding
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0007399
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nervous system development
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GO:0021522
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spinal cord motor neuron differentiation
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GO:0021529
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spinal cord oligodendrocyte cell differentiation
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GO:0021530
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spinal cord oligodendrocyte cell fate specification
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GO:0021794
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thalamus development
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GO:0042552
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myelination
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GO:0045665
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negative regulation of neuron differentiation
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GO:0048663
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neuron fate commitment
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GO:0048709
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oligodendrocyte differentiation
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GO:0048714
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positive regulation of oligodendrocyte differentiation
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Cellular Component |
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PDB ID |
MGI:1355331
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
Q9EQW6
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PhosphoSite |
PhosphoSite-Q9EQW6
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TrEMBL |
Q542S0
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UniProt Splice Variant |
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Entrez Gene |
50913
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UniGene |
Mm.405277
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RefSeq |
NP_058663
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MGI ID |
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MGI Symbol |
Olig2
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OMIM |
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CCDS |
CCDS28323
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HPRD |
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IMGT |
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EMBL |
AB038697
AF232929
AK080615
BC051967
CH466602
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GenPept |
AAF61722
AAH51967
BAB18907
BAC37958
EDL03834
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