Version 5.4
Homo sapiens Gene: DEAF1
Summary
InnateDB Gene IDBG-17595.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DEAF1
Gene Name deformed epidermal autoregulatory factor 1 (Drosophila)
Synonyms MRD24; NUDR; SPN; ZMYND5
Species Homo sapiens
Ensembl Gene ENSG00000177030
Encoded Proteins
IDBP-17609
deformed epidermal autoregulatory factor 1 (Drosophila)
IDBP-589359
deformed epidermal autoregulatory factor 1 (Drosophila)
IDBP-592199
deformed epidermal autoregulatory factor 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a zinc finger domain-containing protein that functions as a regulator of transcription. The encoded proteins binds to its own promoter as well as to that of several target genes. Activity of this protein is important in the regulation of embryonic development. Mutations in this gene have been found in individuals with autosomal dominant mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:644233-706715
Strand Reverse strand
Band p15.5
Transcripts
ENST00000382409 ENSP00000371846
ENST00000527170 ENSP00000431563
ENST00000527658
ENST00000525904
ENST00000530813
ENST00000526790
ENST00000529717 ENSP00000432518
ENST00000525626
ENST00000528864
ENST00000524786
ENST00000529727
ENST00000526857
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001843 neural tube closure
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007281 germ cell development
GO:0009653 anatomical structure morphogenesis
GO:0033599 regulation of mammary gland epithelial cell proliferation
GO:0048706 embryonic skeletal system development
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000058886
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.243994
RefSeq NM_021008
HUGO
OMIM
CCDS CCDS31327
HPRD 04027
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca