Version 5.4
Mus musculus Gene: Il10rb
Summary
InnateDB Gene IDBG-175951.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il10rb
Gene Name interleukin 10 receptor, beta
Synonyms 6620401D04Rik; AI528744; CRF2-4; Crfb4; D16H21S58; D21S58h; IL-10R2; Il10r2
Species Mus musculus
Ensembl Gene ENSMUSG00000022969
Encoded Proteins
IDBP-175953
interleukin 10 receptor, beta
IDBP-534249
interleukin 10 receptor, beta
IDBP-531532
interleukin 10 receptor, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000243646:
The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:91406164-91425834
Strand Forward strand
Band C3.3
Transcripts
ENSMUST00000023691 ENSMUSP00000023691
ENSMUST00000156133 ENSMUSP00000120227
ENSMUST00000144215 ENSMUSP00000120485
ENSMUST00000152729
ENSMUST00000137612
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004920 interleukin-10 receptor activity
GO:0005515 protein binding
Biological Process
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000243646
View Gene Order
ENSBTAG00000019404
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu05145
Toxoplasmosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa05145
Toxoplasmosis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-10 signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL E9Q294 Q8VHM8
UniProt Splice Variant
Entrez Gene 16155
UniGene Mm.4154
RefSeq NM_008349 XM_006522924
OMIM
CCDS CCDS37398
HPRD
IMGT
MGI ID MGI:109380
MGI Symbol Il10rb
EMBL AC152503 AF440786
GenPept AAL40943
RNA Seq Atlas 16155

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca