InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pias3

Summary

InnateDB Gene

IDBG-176105.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pias3

Gene Name

protein inhibitor of activated STAT 3

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028101

Encoded Proteins

IDBP-176107

protein inhibitor of activated STAT 3

IDBP-267422

protein inhibitor of activated STAT 3

IDBP-267424

protein inhibitor of activated STAT 3

IDBP-542825

protein inhibitor of activated STAT 3

IDBP-542552

protein inhibitor of activated STAT 3

IDBP-716170

IDBP-716190

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23998932

[Homo sapiens] MIR21 inhibition enhances CCL5 (RANTES) and CXCL10 (IP-10) release in MCF-7 cancer cells and resulted in increased lymphocyte migration . PIAS3 is a target of MIR21 in MCF-7 cells.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131788:
This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:96696384-96706070

Strand

Forward strand

Band

F2.1

Transcripts

ENSMUST00000064900	ENSMUSP00000069259
ENSMUST00000107077	ENSMUSP00000102692
ENSMUST00000107076	ENSMUSP00000102691
ENSMUST00000162934	ENSMUSP00000125747
ENSMUST00000162778	ENSMUSP00000125377
ENSMUST00000162707
ENSMUST00000161296
ENSMUST00000162156	ENSMUSP00000135843
ENSMUST00000176302	ENSMUSP00000134835
ENSMUST00000176288

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008270	zinc ion binding
GO:0015459	potassium channel regulator activity
GO:0019789	SUMO ligase activity
GO:0019899	enzyme binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009725	response to hormone
GO:0010628	positive regulation of gene expression
GO:0016925	protein sumoylation
GO:0033235	positive regulation of protein sumoylation
GO:0045838	positive regulation of membrane potential