InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PIAS3

Summary

InnateDB Gene

IDBG-633686.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIAS3

Gene Name

E3 SUMO-protein ligase PIAS3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021634

Encoded Proteins

IDBP-685415

E3 SUMO-protein ligase PIAS3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23998932

[Homo sapiens] MIR21 inhibition enhances CCL5 (RANTES) and CXCL10 (IP-10) release in MCF-7 cancer cells and resulted in increased lymphocyte migration . PIAS3 is a target of MIR21 in MCF-7 cells.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131788:
This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:21612696-21622086

Strand

Forward strand

Band

Transcripts

ENSBTAT00000028829

ENSBTAP00000028829

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008270	zinc ion binding
GO:0019789	SUMO ligase activity
GO:0019899	enzyme binding