Version 5.4
Mus musculus Gene: Dhrs9
Summary
InnateDB Gene IDBG-176180.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dhrs9
Gene Name dehydrogenase/reductase (SDR family) member 9
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000027068
Encoded Proteins
IDBP-176182
dehydrogenase/reductase (SDR family) member 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073737:
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:69380445-69404533
Strand Forward strand
Band C2
Transcripts
ENSMUST00000063690 ENSMUSP00000069631
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004022 alcohol dehydrogenase (NAD) activity
GO:0004745 retinol dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0047035 testosterone dehydrogenase (NAD+) activity
Biological Process
GO:0002138 retinoic acid biosynthetic process
GO:0008152 metabolic process
GO:0008209 androgen metabolic process
GO:0042448 progesterone metabolic process
GO:0042904 9-cis-retinoic acid biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000073737
View Gene Order
ENSBTAG00000004557
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00830
Retinol metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160156
The canonical retinoid cycle in rods (twilight vision) pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_116125
Disease pathway
KEGG
hsa00830
Retinol metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q58NB6
TrEMBL Q148Q4
UniProt Splice Variant
Entrez Gene 241452
UniGene Mm.211655
RefSeq NM_175512
OMIM
CCDS CCDS16091
HPRD
IMGT
MGI ID MGI:2442798
MGI Symbol Dhrs9
EMBL AF361479 AK050180 AK080914 AY936479 BC118029 CH466519
GenPept AAI18030 AAN75755 AAX33670 BAC34110 BAC38075 EDL27033
RNA Seq Atlas 241452

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca