InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dhrs9

Summary

InnateDB Protein

IDBP-176182.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dhrs9

Protein Name

dehydrogenase/reductase (SDR family) member 9

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069631

InnateDB Gene

IDBG-176180 (Dhrs9)

Protein Structure

UniProt Annotation

Function

3-alpha-hydroxysteroid dehydrogenase that converts 3- alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Microsome membrane {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Note=Associated with microsomal membranes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004022	alcohol dehydrogenase (NAD) activity
GO:0004745	retinol dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0047035	testosterone dehydrogenase (NAD+) activity

Biological Process

GO:0002138	retinoic acid biosynthetic process
GO:0008152	metabolic process
GO:0008209	androgen metabolic process
GO:0042448	progesterone metabolic process
GO:0042904	9-cis-retinoic acid biosynthetic process
GO:0055114	oxidation-reduction process