Version 5.4
Mus musculus Gene: Mxi1
Summary
InnateDB Gene IDBG-176488.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mxi1
Gene Name Max interacting protein 1
Synonyms bHLHc11; ENSMUSG00000067085; Gm10197; Mad2
Species Mus musculus
Ensembl Gene ENSMUSG00000025025
Encoded Proteins
IDBP-176490
Max interacting protein 1
IDBP-176492
Max interacting protein 1
IDBP-257490
Max interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein containing a helix-loop-helix domain characteristic of transcription factors, which allows heterodimerization and sequence-specific DNA binding. The encoded protein is related to a family of Myc/Max/Mad proteins that are involved in the regulation of several cellular processes. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate Myc function. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:53310506-53375810
Strand Forward strand
Band D2
Transcripts
ENSMUST00000003870 ENSMUSP00000003870
ENSMUST00000025998 ENSMUSP00000025998
ENSMUST00000111737 ENSMUSP00000107366
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000119950
View Gene Order
ENSBTAG00000017263
Not yet available
Cross-References
SwissProt P50540
TrEMBL
UniProt Splice Variant
Entrez Gene 17859
UniGene Mm.2154 Mm.404701 Mm.407419
RefSeq NM_001008543 XM_006526736 XM_006526738 XM_006526739 XM_006526740 XM_006526741 NM_001008542 NM_010847
OMIM
CCDS CCDS38023 CCDS29901 CCDS38022
HPRD
IMGT
MGI ID MGI:97245
MGI Symbol Mxi1
EMBL D31824 L38821 L38822 U24673 U24674
GenPept AAA65182 AAA65183 AAA65684 AAA65685 BAA06612
RNA Seq Atlas 17859

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca