Version 5.4
Mus musculus Gene: Nefl
Summary
InnateDB Gene IDBG-176493.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nefl
Gene Name neurofilament, light polypeptide
Synonyms AI847934; CMT2E; NF-L; NF68; Nfl
Species Mus musculus
Ensembl Gene ENSMUSG00000022055
Encoded Proteins
IDBP-176495
neurofilament, light polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:68083863-68089095
Strand Forward strand
Band D1
Transcripts
ENSMUST00000022639 ENSMUSP00000022639
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0019904 protein domain specific binding
GO:0030674 protein binding, bridging
GO:0042802 identical protein binding
GO:0043274 phospholipase binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0008089 anterograde axon cargo transport
GO:0008090 retrograde axon cargo transport
GO:0009636 response to toxic substance
GO:0010033 response to organic substance
GO:0010243 response to organonitrogen compound
GO:0014012 peripheral nervous system axon regeneration
GO:0019896 axon transport of mitochondrion
GO:0031133 regulation of axon diameter
GO:0033693 neurofilament bundle assembly
GO:0040011 locomotion
GO:0043434 response to peptide hormone
GO:0043524 negative regulation of neuron apoptotic process
GO:0045109 intermediate filament organization
GO:0045110 intermediate filament bundle assembly
GO:0048812 neuron projection morphogenesis
GO:0050772 positive regulation of axonogenesis
GO:0050885 neuromuscular process controlling balance
GO:0051258 protein polymerization
GO:0051412 response to corticosterone
GO:0060052 neurofilament cytoskeleton organization
Cellular Component
GO:0005737 cytoplasm
GO:0005882 intermediate filament
GO:0005883 neurofilament
GO:0030424 axon
GO:0030426 growth cone
GO:0033596 TSC1-TSC2 complex
GO:0043005 neuron projection
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
mmu05014
Amyotrophic lateral sclerosis (ALS) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.406882 Mm.472083
RefSeq NM_010910
OMIM
CCDS CCDS27232
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca