InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nefl

Summary

InnateDB Protein

IDBP-176495.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nefl

Protein Name

neurofilament, light polypeptide

Synonyms

AI847934; CMT2E; NF-L; NF68; Nfl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022639

InnateDB Gene

IDBG-176493 (Nefl)

Protein Structure

UniProt Annotation

Function

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019904	protein domain specific binding
GO:0030674	protein binding, bridging
GO:0042802	identical protein binding
GO:0043274	phospholipase binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0008089	anterograde axon cargo transport
GO:0008090	retrograde axon cargo transport
GO:0009636	response to toxic substance
GO:0010033	response to organic substance
GO:0010243	response to organonitrogen compound
GO:0014012	peripheral nervous system axon regeneration
GO:0019896	axon transport of mitochondrion
GO:0031133	regulation of axon diameter
GO:0033693	neurofilament bundle assembly
GO:0040011	locomotion
GO:0043434	response to peptide hormone
GO:0043524	negative regulation of neuron apoptotic process
GO:0045109	intermediate filament organization
GO:0045110	intermediate filament bundle assembly
GO:0048812	neuron projection morphogenesis
GO:0050772	positive regulation of axonogenesis
GO:0050885	neuromuscular process controlling balance
GO:0051258	protein polymerization
GO:0051412	response to corticosterone
GO:0060052	neurofilament cytoskeleton organization

Cellular Component