InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gadd45b

Summary

InnateDB Gene

IDBG-176557.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gadd45b

Gene Name

growth arrest and DNA-damage-inducible 45 beta

Synonyms

AI323528; Myd118

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015312

Encoded Proteins

IDBP-176559

growth arrest and DNA-damage-inducible 45 beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099860:
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:80930091-80932204

Strand

Forward strand

Band

Transcripts

ENSMUST00000015456

ENSMUSP00000015456

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0000186	activation of MAPKK activity
GO:0006469	negative regulation of protein kinase activity
GO:0006915	apoptotic process
GO:0006950	response to stress
GO:0007275	multicellular organismal development
GO:0030154	cell differentiation
GO:0043065	positive regulation of apoptotic process
GO:0046330	positive regulation of JNK cascade
GO:0051726	regulation of cell cycle
GO:1900745	positive regulation of p38MAPK cascade

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000099860

View Gene Order

ENSBTAG00000025462

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04115

p53 signaling pathway pathway

mmu04110

Cell cycle pathway

mmu04010

MAPK signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04110

Cell cycle pathway

hsa04010

MAPK signaling pathway pathway

hsa04115

p53 signaling pathway pathway

INOH

PID NCI

il12_2pathway

IL12-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.1360

RefSeq

NM_008655

OMIM

CCDS

CCDS24038

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas