InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gadd45b

Summary

InnateDB Protein

IDBP-176559.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gadd45b

Protein Name

growth arrest and DNA-damage-inducible 45 beta

Synonyms

AI323528; Myd118;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015456

InnateDB Gene

IDBG-176557 (Gadd45b)

Protein Structure

UniProt Annotation

Function

Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

In myeloid precursor enriched BM cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0000186	activation of MAPKK activity
GO:0006469	negative regulation of protein kinase activity
GO:0006915	apoptotic process
GO:0006950	response to stress
GO:0007275	multicellular organismal development
GO:0030154	cell differentiation
GO:0043065	positive regulation of apoptotic process
GO:0046330	positive regulation of JNK cascade
GO:0051726	regulation of cell cycle
GO:1900745	positive regulation of p38MAPK cascade