InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Stc1

Summary

InnateDB Gene

IDBG-177019.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stc1

Gene Name

stanniocalcin 1

Synonyms

Stc

Species

Mus musculus

Ensembl Gene

ENSMUSG00000014813

Encoded Proteins

IDBP-177021

stanniocalcin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159167:
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5\' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:69029289-69041401

Strand

Forward strand

Band

Transcripts

ENSMUST00000014957

ENSMUSP00000014957

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity

Biological Process

GO:0001503	ossification
GO:0006874	cellular calcium ion homeostasis
GO:0007566	embryo implantation
GO:0014070	response to organic cyclic compound
GO:0030320	cellular monovalent inorganic anion homeostasis
GO:0033280	response to vitamin D
GO:0046697	decidualization
GO:0071320	cellular response to cAMP
GO:0071385	cellular response to glucocorticoid stimulus
GO:0071456	cellular response to hypoxia

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0016324	apical plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000159167

View Gene Order

ENSBTAG00000001687

Not yet available

Cross-References

SwissProt

O55183

TrEMBL

Q3TSM0 Q3UYW0 Q3UYZ1

UniProt Splice Variant

Entrez Gene

20855

UniGene

Mm.20911 Mm.404151

RefSeq

NM_009285

OMIM

CCDS

CCDS27236

HPRD

IMGT

MGI ID

MGI:109131

MGI Symbol

Stc1

EMBL

AK134260 AK134331 AK149351 AK161960 BC021425 CH466535 U47815

GenPept

AAC00050 AAH21425 BAE22070 BAE22101 BAE28827 BAE36655 EDL35955

RNA Seq Atlas

20855