InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: STC1

Summary

InnateDB Gene

IDBG-12222.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STC1

Gene Name

stanniocalcin 1

Synonyms

STC

Species

Homo sapiens

Ensembl Gene

ENSG00000159167

Encoded Proteins

IDBP-12226

stanniocalcin 1

IDBP-476079

stanniocalcin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5\' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:23841915-23854807

Strand

Reverse strand

Band

p21.2

Transcripts

ENST00000290271	ENSP00000290271
ENST00000524323	ENSP00000427932

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity

Biological Process

GO:0001503	ossification
GO:0006874	cellular calcium ion homeostasis
GO:0007166	cell surface receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007566	embryo implantation
GO:0007584	response to nutrient
GO:0014070	response to organic cyclic compound
GO:0033280	response to vitamin D
GO:0046697	decidualization
GO:0071320	cellular response to cAMP
GO:0071385	cellular response to glucocorticoid stimulus
GO:0071456	cellular response to hypoxia

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0016324	apical plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000014813

View Gene Order

ENSBTAG00000001687

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.25590 Hs.713005 Hs.729703

RefSeq

NM_003155

HUGO

OMIM

CCDS

CCDS6043

HPRD

03115

IMGT

EMBL

GenPept

RNA Seq Atlas