Version 5.4
Mus musculus Gene: Trpc5
Summary
InnateDB Gene IDBG-177241.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trpc5
Gene Name transient receptor potential cation channel, subfamily C, member 5
Synonyms CCE2; TRP-5; TRP5; Trrp5
Species Mus musculus
Ensembl Gene ENSMUSG00000041710
Encoded Proteins
IDBP-177243
transient receptor potential cation channel, subfamily C, member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072315:
This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:144381671-144688180
Strand Reverse strand
Band F2
Transcripts
ENSMUST00000040184 ENSMUSP00000049063
ENSMUST00000148240
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 ion transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0034704 calcium channel complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000072315
View Gene Order
ENSBTAG00000010065
Not yet available
Pathways
NETPATH
REACTOME
REACT_196640
Stimuli-sensing channels pathway
REACT_229826
Netrin-1 signaling pathway
REACT_230631
Role of second messengers in netrin-1 signaling pathway
REACT_262350
Ion channel transport pathway
REACT_261444
Axon guidance pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_188576
Developmental Biology pathway
REACT_227861
TRP channels pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_22228
Role of second messengers in netrin-1 signaling pathway
REACT_22237
Netrin-1 signaling pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
REACT_25300
Ion channel transport pathway
REACT_169333
TRP channels pathway
REACT_214777
TRP channels pathway
REACT_223895
Ion channel transport pathway
REACT_205744
Netrin-1 signaling pathway
REACT_223103
Transmembrane transport of small molecules pathway
REACT_203140
Axon guidance pathway
REACT_209343
Role of second messengers in netrin-1 signaling pathway
REACT_213748
Stimuli-sensing channels pathway
REACT_220844
Developmental Biology pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.328378
RefSeq NM_009428
OMIM
CCDS CCDS30457
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca