Version 5.4
Mus musculus Gene: Lst1
Summary
InnateDB Gene IDBG-177285.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lst1
Gene Name leukocyte specific transcript 1
Synonyms B144
Species Mus musculus
Ensembl Gene ENSMUSG00000073412
Encoded Proteins
IDBP-177287
leukocyte specific transcript 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22589543
Lst1 recruits tyrosine-phosphorylated Ptpn6 and Ptpn11 to the plasma membrane in myeloid leukocytes. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
PMID 22589543
[Homo sapiens] LST1 recruits tyrosine-phosphorylated PTPN6 and PTPN11 to the plasma membrane in myeloid leukocytes.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204482:
The protein encoded by this gene is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:35185095-35188439
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000097336 ENSMUSP00000094949
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000902 cell morphogenesis
GO:0006955 immune response
GO:0016358 dendrite development
GO:0045087 innate immune response (InnateDB)
GO:0050672 negative regulation of lymphocyte proliferation
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000204482
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.19379
RefSeq NM_010734
OMIM
CCDS CCDS50085
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca