Version 5.4
Mus musculus Gene: Il17rc
Summary
InnateDB Gene IDBG-177405.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il17rc
Gene Name interleukin 17 receptor C
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000030281
Encoded Proteins
IDBP-177407
interleukin 17 receptor C
IDBP-254666
interleukin 17 receptor C
IDBP-542322
interleukin 17 receptor C
IDBP-534679
interleukin 17 receptor C
IDBP-534798
interleukin 17 receptor C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163702:
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:113471427-113483140
Strand Forward strand
Band E3
Transcripts
ENSMUST00000058300 ENSMUSP00000055343
ENSMUST00000113062 ENSMUSP00000108685
ENSMUST00000147316 ENSMUSP00000123243
ENSMUST00000149899 ENSMUSP00000122986
ENSMUST00000142082 ENSMUSP00000114774
ENSMUST00000131969
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030368 interleukin-17 receptor activity
Biological Process
GO:0019221 cytokine-mediated signaling pathway
GO:1900017 positive regulation of cytokine production involved in inflammatory response
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163702
View Gene Order
ENSBTAG00000033669
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_134159 NM_178942 XM_006505667 XM_006505668 XM_006505669
OMIM
CCDS CCDS20422
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca