Version 5.4
Mus musculus Gene: Matk
Summary
InnateDB Gene IDBG-177503.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Matk
Gene Name megakaryocyte-associated tyrosine kinase
Synonyms CHK; HYL; Ntk
Species Mus musculus
Ensembl Gene ENSMUSG00000004933
Encoded Proteins
IDBP-271108
megakaryocyte-associated tyrosine kinase
IDBP-400733
megakaryocyte-associated tyrosine kinase
IDBP-400734
megakaryocyte-associated tyrosine kinase
IDBP-400732
megakaryocyte-associated tyrosine kinase
IDBP-400731
megakaryocyte-associated tyrosine kinase
IDBP-535545
megakaryocyte-associated tyrosine kinase
IDBP-538920
megakaryocyte-associated tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000007264:
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:81252935-81263365
Strand Forward strand
Band C1
Transcripts
ENSMUST00000105328 ENSMUSP00000100965
ENSMUST00000117488 ENSMUSP00000113221
ENSMUST00000119547 ENSMUSP00000113576
ENSMUST00000121205 ENSMUSP00000113043
ENSMUST00000120265 ENSMUSP00000113666
ENSMUST00000128576 ENSMUSP00000122445
ENSMUST00000150605
ENSMUST00000126720
ENSMUST00000130282 ENSMUSP00000114233
ENSMUST00000151660
ENSMUST00000148735
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000007264
View Gene Order
ENSBTAG00000006619
Not yet available
Pathways
NETPATH
REACTOME
REACT_188191
Signaling by ERBB2 pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04722
Neurotrophin signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
REACTOME
REACT_115755
Signaling by ERBB2 pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04722
Neurotrophin signaling pathway pathway
INOH
PID NCI
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cross-References
SwissProt P41242
TrEMBL D3YVQ8
UniProt Splice Variant
Entrez Gene 17179
UniGene Mm.2918 Mm.481164 Mm.481454
RefSeq NM_001285854 NM_001285853 NM_001285855 NM_010768 XM_006513294 XM_006513295 XM_006513296 XM_006513297 XM_006513298 XM_006513299 XM_006513300
OMIM
CCDS CCDS70078 CCDS24048 CCDS70077
HPRD
IMGT
MGI ID MGI:99259
MGI Symbol Matk
EMBL AC155932 D45243 L27738 L33339 U05210
GenPept AAA18829 AAA64431 AAB59677 BAA08199
RNA Seq Atlas 17179

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca