InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Matk

Summary

InnateDB Protein

IDBP-400733.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Matk

Protein Name

megakaryocyte-associated tyrosine kinase

Synonyms

CHK; HYL; Ntk;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113221

InnateDB Gene

IDBG-177503 (Matk)

Protein Structure

UniProt Annotation

Function

Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:7970703}. Membrane {ECO:0000250}. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Most abundant in brain, and to a lesser extent in the spleen, the thymus and the liver. Also found in the T-cell lineage.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:99259

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00017
PF14633
PF07714
PF00018
PF14604

PRINTS

PR00401
PR00109
PR00452

PIRSF

SMART

SM00252
SM00326
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt