Version 5.4
Mus musculus Gene: Klk7
Summary
InnateDB Gene IDBG-177568.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Klk7
Gene Name kallikrein related-peptidase 7 (chymotryptic, stratum corneum)
Synonyms Prss6; SCCE
Species Mus musculus
Ensembl Gene ENSMUSG00000030713
Encoded Proteins
IDBP-177570
kallikrein related-peptidase 7 (chymotryptic, stratum corneum)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169035:
This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:43811444-43816359
Strand Forward strand
Band B3
Transcripts
ENSMUST00000032955 ENSMUSP00000032955
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region
GO:0097209 epidermal lamellar body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000169035
View Gene Order
ENSBTAG00000030483
Not yet available
Pathways
NETPATH
REACTOME
REACT_206066
Extracellular matrix organization pathway
REACT_199052
Degradation of the extracellular matrix pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q91VE3
TrEMBL
UniProt Splice Variant
Entrez Gene 23993
UniGene Mm.251227 Mm.398924
RefSeq NM_011872
OMIM
CCDS CCDS21183
HPRD
IMGT
MGI ID MGI:1346336
MGI Symbol Klk7
EMBL AB008371 AF124299 AF339930 AK029477 AK077406 BC027823
GenPept AAF01139 AAH27823 AAK69652 BAB55604 BAC26467 BAC36787
RNA Seq Atlas 23993

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca