Version 5.4
Mus musculus Gene: Tnfrsf10b
Summary
InnateDB Gene IDBG-177623.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnfrsf10b
Gene Name tumor necrosis factor receptor superfamily, member 10b
Synonyms DR5; KILLER; Ly98; MK; TRAILR2; TRICK2A; TRICK2B; TRICKB
Species Mus musculus
Ensembl Gene ENSMUSG00000022074
Encoded Proteins
IDBP-177625
tumor necrosis factor receptor superfamily, member 10b
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:69767472-69784403
Strand Forward strand
Band D2
Transcripts
ENSMUST00000022663 ENSMUSP00000022663
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0045569 TRAIL binding
Biological Process
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0008584 male gonad development
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0010033 response to organic substance
GO:0014070 response to organic cyclic compound
GO:0034976 response to endoplasmic reticulum stress
GO:0042981 regulation of apoptotic process
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_258521
Apoptosis pathway
REACT_243608
Dimerization of procaspase-8 pathway
REACT_241657
Caspase-8 activation by cleavage pathway
REACT_253999
TRAIL signaling pathway
REACT_257735
Death Receptor Signalling pathway
REACT_215122
Regulation by c-FLIP pathway
REACT_259850
Extrinsic Pathway for Apoptosis pathway
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu04210
Apoptosis pathway
INOH
PID NCI
Cross-References
SwissProt Q9QZM4
TrEMBL
UniProt Splice Variant
Entrez Gene 21933
UniGene Mm.193430
RefSeq NM_020275
OMIM
CCDS CCDS27243
HPRD
IMGT
MGI ID MGI:1341090
MGI Symbol Tnfrsf10b
EMBL AB031081 AB031082 AF176833 AK050753 AK080069 AK154993 BC065141
GenPept AAD52656 AAH65141 BAA96462 BAA96463 BAC34404 BAC37821 BAE32980
RNA Seq Atlas 21933

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca