InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnfrsf10b

Summary

InnateDB Protein

IDBP-177625.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfrsf10b

Protein Name

tumor necrosis factor receptor superfamily, member 10b

Synonyms

DR5; KILLER; Ly98; MK; TRAILR2; TRICK2A; TRICK2B; TRICKB;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022663

InnateDB Gene

IDBG-177623 (Tnfrsf10b)

Protein Structure

UniProt Annotation

Function

Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in heart, lung and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0045569	TRAIL binding

Biological Process

GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165	signal transduction
GO:0008584	male gonad development
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0010033	response to organic substance
GO:0014070	response to organic cyclic compound
GO:0034976	response to endoplasmic reticulum stress
GO:0042981	regulation of apoptotic process
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress