Version 5.4
Mus musculus Gene: Cbr3
Summary
InnateDB Gene IDBG-177895.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cbr3
Gene Name carbonyl reductase 3
Synonyms 1110001J05Rik; C81353
Species Mus musculus
Ensembl Gene ENSMUSG00000022947
Encoded Proteins
IDBP-177897
carbonyl reductase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159231:
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008]
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:93683215-93690990
Strand Forward strand
Band C4
Transcripts
ENSMUST00000039620 ENSMUSP00000047712
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000253 3-keto sterol reductase activity
GO:0004090 carbonyl reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0070402 NADPH binding
Biological Process
GO:0008152 metabolic process
GO:0042376 phylloquinone catabolic process
GO:0050890 cognition
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000159231
View Gene Order
ENSBTAG00000018688
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00590
Arachidonic acid metabolism pathway
mmu00980
Metabolism of xenobiotics by cytochrome P450 pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00590
Arachidonic acid metabolism pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
INOH
INOH website
Prostaglandin Leukotriene metabolism pathway
PID NCI
Cross-References
SwissProt Q8K354
TrEMBL
UniProt Splice Variant
Entrez Gene 109857
UniGene Mm.4512
RefSeq NM_173047
OMIM
CCDS CCDS28342
HPRD
IMGT
MGI ID MGI:1309992
MGI Symbol Cbr3
EMBL AC154449 AK028150 BC028763 BC087735 BC096658 CH466602
GenPept AAH28763 AAH87735 AAH96658 BAC25778 EDL03763
RNA Seq Atlas 109857

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca