Version 5.4
| Mus musculus Gene: Klk1b26 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-177954.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | Klk1b26 | ||||||||||||||||||
| Gene Name | kallikrein 1-related petidase b26 | ||||||||||||||||||
| Synonyms | Egfbp-2; Egfbp2; Klk1b26; Klk26; mGk-13; mGK-26; mGK26; PRECE-2 | ||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||
| Ensembl Gene | ENSMUSG00000053719 | ||||||||||||||||||
| Encoded Proteins |
kallikrein 1-related petidase b26
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene belongs to the kallikrein family, which is a highly homologous group of serine proteases encoded by a cluster of related genes on chromosome 7. This gene has been shown to function as both a prorenin converting enzyme and as epidermal growth factor (EGF)-binding protein involved in the maturation of EGF (PMIDs: 1918045, 3322387, 9685728). This gene is thought to be distinct from Klk1b26 gene (GeneID:16618), with which it shares 98% identity (PMID:1959648, 9685728), however, it is not clear if both genes are present in all strains of mice. Blast analyses suggest that this gene is missing from the current reference (GRCm38, based on C57BL/6J genome) and alternate Celera (based on mixed strain genomes) assemblies. Therefore, the RefSeq for this locus was based on sequence from the ICR strain, which has been reported in literature (PMID:1959648) to contain both genes. [provided by RefSeq, Aug 2012] The protein encoded by this gene belongs to the kallikrein family, which is a highly homologous group of serine proteases encoded by a cluster of related genes on chromosome 7. This gene has been shown to function as both a prorenin converting enzyme and as epidermal growth factor (EGF)-binding protein involved in the maturation of EGF (PMIDs: 1918045, 3322387, 9685728). This gene is thought to be distinct from Klk1b26 gene (GeneID:16618), with which it shares 98%% identity (PMID:1959648, 9685728), however, it is not clear if both genes are present in all strains of mice. Blast analyses suggest that this gene is missing from the current reference (GRCm38, based on C57BL/6J genome) and alternate Celera (based on mixed strain genomes) assemblies. Therefore, the RefSeq for this locus was based on sequence from the ICR strain, which has been reported in literature (PMID:1959648) to contain both genes. [provided by RefSeq, Aug 2012] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 7:44012678-44016965 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | B3 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Activation of Matrix Metalloproteinases pathway
Extracellular matrix organization pathway
Metabolism of proteins pathway
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
Degradation of the extracellular matrix pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P36369 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 16618 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_010115 NM_010644 XM_006540676 | ||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS39938 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| MGI ID | MGI:891981 | ||||||||||||||||||
| MGI Symbol | Klk1b26 | ||||||||||||||||||
| EMBL | BC024688 BC138704 K01831 V00828 X63327 | ||||||||||||||||||
| GenPept | AAA37540 AAH24688 AAI38705 CAA24211 CAA44931 | ||||||||||||||||||
| RNA Seq Atlas | 13647 16618 | ||||||||||||||||||