Version 5.4
Mus musculus Gene: Cox18
Summary
InnateDB Gene IDBG-178006.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cox18
Gene Name COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000035505
Encoded Proteins
IDBP-178008
COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)
IDBP-400613
COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)
IDBP-533708
COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163626:
COX18 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox18 protein catalyzes the insertion of the Cox2 (MTCO2; MIM 516040) C-terminal tail into the mitochondrial inner membrane, an intermediate step in the assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 [PubMed 16212937]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:90214724-90224001
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000048363 ENSMUSP00000044144
ENSMUST00000118816 ENSMUSP00000113353
ENSMUST00000144898
ENSMUST00000133905
ENSMUST00000131068
ENSMUST00000148480 ENSMUSP00000116430
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008565 protein transporter activity
Biological Process
GO:0008535 respiratory chain complex IV assembly
GO:0015031 protein transport
GO:0051204 protein insertion into mitochondrial membrane
GO:0051205 protein insertion into membrane
Cellular Component
GO:0005739 mitochondrion
GO:0016021 integral component of membrane
GO:0031305 integral component of mitochondrial inner membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163626
View Gene Order
ENSBTAG00000005394
Not yet available
Pathways
NETPATH
REACTOME
REACT_189162
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_268398
Orphan transporters pathway
REACT_262523
Respiratory electron transport pathway
REACT_188937
Metabolism pathway
REACT_261922
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22393
Respiratory electron transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_6305
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_267716
Orphan transporters pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G5E8U6
UniProt Splice Variant
Entrez Gene 231430
UniGene Mm.319697
RefSeq NM_001163456 NM_001033310
OMIM
CCDS CCDS51543 CCDS19411
HPRD
IMGT
MGI ID MGI:2448532
MGI Symbol Cox18
EMBL AC162171 CH466617
GenPept EDL05331
RNA Seq Atlas 231430

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca