Version 5.4
Homo sapiens Gene: COX18
Summary
InnateDB Gene IDBG-23258.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COX18
Gene Name cytochrome c oxidase assembly homolog 18 (yeast)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163626
Encoded Proteins
IDBP-23260
COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)
IDBP-370382
COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)
IDBP-484861
COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)
IDBP-480287
COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary COX18 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox18 protein catalyzes the insertion of the Cox2 (MTCO2; MIM 516040) C-terminal tail into the mitochondrial inner membrane, an intermediate step in the assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 [PubMed 16212937]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:73056080-73069755
Strand Reverse strand
Band q13.3
Transcripts
ENST00000295890 ENSP00000295890
ENST00000449739 ENSP00000394583
ENST00000421792
ENST00000507544 ENSP00000425261
ENST00000510031 ENSP00000424978
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008565 protein transporter activity
Biological Process
GO:0008535 respiratory chain complex IV assembly
GO:0015031 protein transport
GO:0051204 protein insertion into mitochondrial membrane
GO:0051205 protein insertion into membrane
Cellular Component
GO:0005739 mitochondrion
GO:0016021 integral component of membrane
GO:0031305 integral component of mitochondrial inner membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035505
View Gene Order
ENSBTAG00000005394
Not yet available
Pathways
NETPATH
REACTOME
REACT_22393
Respiratory electron transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_6305
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_267716
Orphan transporters pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.356697 Hs.707136
RefSeq NM_001297732 NM_001297733 NM_001300729 NM_173827 XM_005265679 XM_005265680
HUGO
OMIM
CCDS CCDS3554 CCDS75139
HPRD 08249
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca