Version 5.4
Mus musculus Gene: Pdlim2
Summary
InnateDB Gene IDBG-178026.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pdlim2
Gene Name PDZ and LIM domain 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000022090
Encoded Proteins
IDBP-178028
PDZ and LIM domain 2
IDBP-534532
PDZ and LIM domain 2
IDBP-788709
PDZ and LIM domain 2
IDBP-788710
PDZ and LIM domain 2
IDBP-534822
PDZ and LIM domain 2
IDBP-534000
PDZ and LIM domain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120913:
This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:70164218-70177681
Strand Reverse strand
Band D2
Transcripts
ENSMUST00000022681 ENSMUSP00000022681
ENSMUST00000153735 ENSMUSP00000116200
ENSMUST00000129174 ENSMUSP00000139820
ENSMUST00000127836 ENSMUSP00000141050
ENSMUST00000125300 ENSMUSP00000116694
ENSMUST00000143393 ENSMUSP00000119222
ENSMUST00000141363
ENSMUST00000135944
ENSMUST00000138792
ENSMUST00000123125
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0031005 filamin binding
GO:0032036 myosin heavy chain binding
GO:0051371 muscle alpha-actinin binding
GO:0051393 alpha-actinin binding
Biological Process
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0030864 cortical actin cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000120913
View Gene Order
ENSBTAG00000007369
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.283968 Mm.489788
RefSeq NM_001253736 NM_145978 XM_006518781 XM_006518783
OMIM
CCDS CCDS27248
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca