InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pdlim2

Summary

InnateDB Protein

IDBP-178028.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdlim2

Protein Name

PDZ and LIM domain 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022681

InnateDB Gene

IDBG-178026 (Pdlim2)

Protein Structure

UniProt Annotation

Function

Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton. Note=Localizes at the cytoskeleton. Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN) (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in lung. Expressed at intermediate level in kidney, testis and spleen. Weakly expressed in heart and brain. {ECO:0000269PubMed:15659642}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031005	filamin binding
GO:0032036	myosin heavy chain binding
GO:0051371	muscle alpha-actinin binding