Version 5.4
Mus musculus Gene: Scaf11
Summary
InnateDB Gene IDBG-178155.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Scaf11
Gene Name SR-related CTD-associated factor 11
Synonyms 1110061H03Rik; 2610510E10Rik; AI462454; CASP11; mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip
Species Mus musculus
Ensembl Gene ENSMUSG00000033228
Encoded Proteins
IDBP-178157
SR-related CTD-associated factor 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22895188
Caspase-11 (SCAF11) increases susceptibility to Salmonella infection in the absence of caspase-1.
PMID 23348507
SCAF11 (Caspase 11) is required for innate surveillance against bacteria that escape the vacuole.
InnateDB Annotation from Orthologs
Summary
PMID 22895188
[Homo sapiens] Caspase-11 (SCAF11) increases susceptibility to Salmonella infection in the absence of caspase-1. (Demonstrated in mouse)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139218:
Gene Information
Type Protein coding
Genomic Location Chromosome 15:96411698-96460843
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000047835 ENSMUSP00000044898
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0008380 RNA splicing
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000139218
View Gene Order
ENSBTAG00000001810
Not yet available
Cross-References
SwissProt
TrEMBL E9PZM7 Q810T0 Q9CSS1
UniProt Splice Variant
Entrez Gene 72193
UniGene Mm.324474 Mm.400467
RefSeq NM_028148
OMIM
CCDS CCDS37186
HPRD
IMGT
MGI ID MGI:1919443
MGI Symbol Scaf11
EMBL AC133578 AC158769 AK012092 BC048359
GenPept AAH48359 BAB28024
RNA Seq Atlas 72193

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca