InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Taf9

Summary

InnateDB Gene

IDBG-178346.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Taf9

Gene Name

TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000052293

Encoded Proteins

IDBP-178348

TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor

IDBP-625494

TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor

IDBP-790130

TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor

IDBP-790131

TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor

IDBP-790132

TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor

IDBP-790133

TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085231:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators such as p53 and VP16. A similar but distinct gene (TAF9L) has been found on the X chromosome and a pseudogene has been identified on chromosome 19. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:100651579-100656060

Strand

Forward strand

Band

Transcripts

ENSMUST00000084721	ENSMUSP00000081772
ENSMUST00000167256	ENSMUSP00000132143
ENSMUST00000190165	ENSMUSP00000139407
ENSMUST00000185767	ENSMUSP00000140423
ENSMUST00000187792	ENSMUSP00000140051
ENSMUST00000190594	ENSMUSP00000140244

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	79 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0033613	activating transcription factor binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0006352	DNA-templated transcription, initiation
GO:0030307	positive regulation of cell growth
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043966	histone H3 acetylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050821	protein stabilization
GO:0060760	positive regulation of response to cytokine stimulus
GO:0070555	response to interleukin-1

Cellular Component

GO:0000125	PCAF complex
GO:0005634	nucleus
GO:0005669	transcription factor TFIID complex
GO:0030914	STAGA complex
GO:0033276	transcription factor TFTC complex
GO:0070761	pre-snoRNP complex
GO:0071339	MLL1 complex