InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Taf9

Summary

InnateDB Protein

IDBP-178348.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Taf9

Protein Name

TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081772

InnateDB Gene

IDBG-178346 (Taf9)

Protein Structure

UniProt Annotation

Function

Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	79 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0033613	activating transcription factor binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0006352	DNA-templated transcription, initiation
GO:0030307	positive regulation of cell growth
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043966	histone H3 acetylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050821	protein stabilization
GO:0060760	positive regulation of response to cytokine stimulus
GO:0070555	response to interleukin-1

Cellular Component

GO:0000125	PCAF complex
GO:0005634	nucleus
GO:0005669	transcription factor TFIID complex
GO:0030914	STAGA complex
GO:0033276	transcription factor TFTC complex
GO:0070761	pre-snoRNP complex
GO:0071339	MLL1 complex