Version 5.4
Mus musculus Gene: Wnt3a
Summary
InnateDB Gene IDBG-178528.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wnt3a
Gene Name wingless-related MMTV integration site 3A
Synonyms vt; Wnt-3a
Species Mus musculus
Ensembl Gene ENSMUSG00000009900
Encoded Proteins
IDBP-178530
wingless-related MMTV integration site 3A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 22328140
[Homo sapiens] WNT3A in human chondrocytes counteracts IL1B induced NF-kB mediated matrix metalloproteinases expression in a negative feedback loop.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154342:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:59248033-59290752
Strand Reverse strand
Band B1.3
Transcripts
ENSMUST00000010044 ENSMUSP00000010044
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005102 receptor binding
GO:0005109 frizzled binding
GO:0005110 frizzled-2 binding
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0048018 receptor agonist activity
Biological Process
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001756 somitogenesis
GO:0001934 positive regulation of protein phosphorylation
GO:0001947 heart looping
GO:0002092 positive regulation of receptor internalization
GO:0003136 negative regulation of heart induction by canonical Wnt receptor signaling pathway
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007275 multicellular organismal development
GO:0007368 determination of left/right symmetry
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007498 mesoderm development
GO:0008284 positive regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0010387 COP9 signalosome assembly
GO:0010977 negative regulation of neuron projection development
GO:0016055 Wnt signaling pathway
GO:0021527 spinal cord association neuron differentiation
GO:0021766 hippocampus development
GO:0021846 cell proliferation in forebrain
GO:0021874 Wnt receptor signaling pathway involved in forebrain neuroblast division
GO:0021904 dorsal/ventral neural tube patterning
GO:0030097 hemopoiesis
GO:0030168 platelet activation
GO:0030198 extracellular matrix organization
GO:0030509 BMP signaling pathway
GO:0030879 mammary gland development
GO:0030890 positive regulation of B cell proliferation
GO:0032092 positive regulation of protein binding
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034613 cellular protein localization
GO:0035413 positive regulation of catenin import into nucleus
GO:0035914 skeletal muscle cell differentiation
GO:0036342 post-anal tail morphogenesis
GO:0042472 inner ear morphogenesis
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045595 regulation of cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048103 somatic stem cell division
GO:0048337 positive regulation of mesodermal cell fate specification
GO:0048343 paraxial mesodermal cell fate commitment
GO:0048697 positive regulation of collateral sprouting in absence of injury
GO:0048843 negative regulation of axon extension involved in axon guidance
GO:0050768 negative regulation of neurogenesis
GO:0050770 regulation of axonogenesis
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060021 palate development
GO:0060070 canonical Wnt signaling pathway
GO:0060923 cardiac muscle cell fate commitment
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0061184 positive regulation of dermatome development
GO:0061317 canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0070527 platelet aggregation
GO:0090245 axis elongation involved in somitogenesis
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin
GO:2000081 positive regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation
GO:2000727 positive regulation of cardiac muscle cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0009986 cell surface
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000154342
View Gene Order
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_254215
Signaling by GPCR pathway
REACT_250061
Class B/2 (Secretin family receptors) pathway
REACT_213918
WNT ligand biogenesis and trafficking pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_213035
regulation of FZD by ubiquitination pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_216784
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_210612
negative regulation of TCF-dependent signaling by WNT ligand antagonists pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_231468
GPCR ligand binding pathway
REACT_246422
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
REACT_188257
Signal Transduction pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
mmu05217
Basal cell carcinoma pathway
mmu04916
Melanogenesis pathway
mmu04310
Wnt signaling pathway pathway
mmu04340
Hedgehog signaling pathway pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
Wnt signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_8
Wnt pathway
REACTOME
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_14797
Signaling by GPCR pathway
REACT_200610
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_228014
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
REACT_111102
Signal Transduction pathway
REACT_163710
WNT ligand biogenesis and trafficking pathway
REACT_200716
regulation of FZD by ubiquitination pathway
REACT_200643
negative regulation of TCF-dependent signaling by WNT ligand antagonists pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_21340
GPCR ligand binding pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
hsa04310
Wnt signaling pathway pathway
hsa04340
Hedgehog signaling pathway pathway
hsa05217
Basal cell carcinoma pathway
hsa04916
Melanogenesis pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
Wnt signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
wnt_signaling_pathway
Wnt signaling network
wnt_canonical_pathway
Canonical Wnt signaling pathway
betacatenin_deg_pathway
Degradation of beta catenin
Cross-References
SwissProt P27467
TrEMBL
UniProt Splice Variant
Entrez Gene 22416
UniGene Mm.1367
RefSeq NM_009522
OMIM
CCDS CCDS24766
HPRD
IMGT
MGI ID MGI:98956
MGI Symbol Wnt3a
EMBL X56842
GenPept CAA40173
RNA Seq Atlas 22416

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca