InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WNT3A

Summary

InnateDB Gene

IDBG-107120.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT3A

Gene Name

wingless-type MMTV integration site family, member 3A

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000154342

Encoded Proteins

IDBP-107122

wingless-type MMTV integration site family, member 3A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22328140

WNT3A in human chondrocytes counteracts IL1B induced NF-kB mediated matrix metalloproteinases expression in a negative feedback loop.

Entrez Gene

Summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:228007051-228061260

Strand

Forward strand

Band

q42.13

Transcripts

ENST00000284523

ENSP00000284523

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005110	frizzled-2 binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0048018	receptor agonist activity

Biological Process

GO:0001649	osteoblast differentiation
GO:0001701	in utero embryonic development
GO:0001756	somitogenesis
GO:0001934	positive regulation of protein phosphorylation
GO:0001947	heart looping
GO:0002092	positive regulation of receptor internalization
GO:0003136	negative regulation of heart induction by canonical Wnt receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0007368	determination of left/right symmetry
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0007498	mesoderm development
GO:0008284	positive regulation of cell proliferation
GO:0009952	anterior/posterior pattern specification
GO:0010387	COP9 signalosome assembly
GO:0010977	negative regulation of neuron projection development
GO:0016055	Wnt signaling pathway
GO:0021527	spinal cord association neuron differentiation
GO:0021766	hippocampus development
GO:0021846	cell proliferation in forebrain
GO:0021874	Wnt receptor signaling pathway involved in forebrain neuroblast division
GO:0021904	dorsal/ventral neural tube patterning
GO:0030097	hemopoiesis
GO:0030168	platelet activation
GO:0030182	neuron differentiation
GO:0030198	extracellular matrix organization
GO:0030879	mammary gland development
GO:0030890	positive regulation of B cell proliferation
GO:0032092	positive regulation of protein binding
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034613	cellular protein localization
GO:0035413	positive regulation of catenin import into nucleus
GO:0035914	skeletal muscle cell differentiation
GO:0036342	post-anal tail morphogenesis
GO:0042472	inner ear morphogenesis
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045595	regulation of cell differentiation
GO:0045599	negative regulation of fat cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048103	somatic stem cell division
GO:0048337	positive regulation of mesodermal cell fate specification
GO:0048343	paraxial mesodermal cell fate commitment
GO:0048697	positive regulation of collateral sprouting in absence of injury
GO:0048843	negative regulation of axon extension involved in axon guidance
GO:0050768	negative regulation of neurogenesis
GO:0050770	regulation of axonogenesis
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060021	palate development
GO:0060070	canonical Wnt signaling pathway
GO:0060923	cardiac muscle cell fate commitment
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0061184	positive regulation of dermatome development
GO:0061317	canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment
GO:0070507	regulation of microtubule cytoskeleton organization
GO:0070527	platelet aggregation
GO:0071300	cellular response to retinoic acid
GO:0090245	axis elongation involved in somitogenesis
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin
GO:2000081	positive regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation
GO:2000727	positive regulation of cardiac muscle cell differentiation

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0009986	cell surface