Version 5.4
Mus musculus Gene: Prdx1
Summary
InnateDB Gene IDBG-178542.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prdx1
Gene Name peroxiredoxin 1
Synonyms MSP23; NkefA; OSF-3; OSF3; PAG; Paga; PrdxI; prx1; PrxI; Tdpx2; TDX2; TPxA
Species Mus musculus
Ensembl Gene ENSMUSG00000028691
Encoded Proteins
IDBP-178544
peroxiredoxin 1
IDBP-268707
peroxiredoxin 1
IDBP-538949
peroxiredoxin 1
IDBP-539730
peroxiredoxin 1
IDBP-533245
peroxiredoxin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117450:
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:116685544-116700822
Strand Forward strand
Band D1
Transcripts
ENSMUST00000030454 ENSMUSP00000030454
ENSMUST00000106470 ENSMUSP00000102078
ENSMUST00000135573 ENSMUSP00000114159
ENSMUST00000151129 ENSMUSP00000119794
ENSMUST00000156145
ENSMUST00000129315 ENSMUSP00000117007
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 75 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004601 peroxidase activity
GO:0005515 protein binding
GO:0008379 thioredoxin peroxidase activity
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
GO:0051920 peroxiredoxin activity
Biological Process
GO:0000302 response to reactive oxygen species
GO:0001895 retina homeostasis
GO:0006979 response to oxidative stress
GO:0008283 cell proliferation
GO:0019430 removal of superoxide radicals
GO:0032872 regulation of stress-activated MAPK cascade
GO:0034101 erythrocyte homeostasis
GO:0042267 natural killer cell mediated cytotoxicity
GO:0042345 regulation of NF-kappaB import into nucleus
GO:0042744 hydrogen peroxide catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005719 nuclear euchromatin
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000117450
View Gene Order
ENSBTAG00000003642
Not yet available
Pathways
NETPATH
REACTOME
REACT_188957
Cellular responses to stress pathway
REACT_189141
Detoxification of Reactive Oxygen Species pathway
KEGG
mmu04146
Peroxisome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_172715
Detoxification of Reactive Oxygen Species pathway
REACT_206069
Cellular responses to stress pathway
REACT_204534
Detoxification of Reactive Oxygen Species pathway
KEGG
hsa04146
Peroxisome pathway
INOH
PID NCI
ar_pathway
Coregulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.413037 Mm.471800
RefSeq NM_011034
OMIM
CCDS CCDS18515
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca