InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRDX1

Summary

InnateDB Gene

IDBG-97953.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRDX1

Gene Name

peroxiredoxin 1

Synonyms

MSP23; NKEF-A; NKEFA; PAG; PAGA; PAGB; PRX1; PRXI; TDPX2

Species

Homo sapiens

Ensembl Gene

ENSG00000117450

Encoded Proteins

IDBP-97955

peroxiredoxin 1

IDBP-97957

peroxiredoxin 1

IDBP-97959

peroxiredoxin 1

IDBP-383186

peroxiredoxin 1

IDBP-383188

peroxiredoxin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:45511036-45523047

Strand

Reverse strand

Band

p34.1

Transcripts

ENST00000262746	ENSP00000262746
ENST00000319248	ENSP00000361152
ENST00000372079	ENSP00000361150
ENST00000424390	ENSP00000389047
ENST00000447184	ENSP00000407034
ENST00000483583

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 108 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	108 [view]
Protein-Protein	108 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0005515	protein binding
GO:0008379	thioredoxin peroxidase activity
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding
GO:0051920	peroxiredoxin activity

Biological Process

GO:0000302	response to reactive oxygen species
GO:0001501	skeletal system development
GO:0001895	retina homeostasis
GO:0006979	response to oxidative stress
GO:0008283	cell proliferation
GO:0019430	removal of superoxide radicals
GO:0032872	regulation of stress-activated MAPK cascade
GO:0034101	erythrocyte homeostasis
GO:0042267	natural killer cell mediated cytotoxicity
GO:0042345	regulation of NF-kappaB import into nucleus
GO:0042744	hydrogen peroxide catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005719	nuclear euchromatin
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005782	peroxisomal matrix
GO:0005829	cytosol
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028691

View Gene Order

ENSBTAG00000003642

Not yet available

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_172715

Detoxification of Reactive Oxygen Species pathway

KEGG

hsa04146

Peroxisome pathway

INOH

PID NCI

ar_pathway

Coregulation of Androgen receptor activity

Cross-References

SwissProt

Q06830

TrEMBL

UniProt Splice Variant

Entrez Gene

5052

UniGene

Hs.681569

RefSeq

NM_001202431 NM_002574 NM_181696 NM_181697

HUGO

HGNC:9352

OMIM

176763

CCDS

CCDS522

HPRD

IMGT

EMBL

AB451262 AB451388 AL451136 BC007063 BC021683 BT019740 CH471059 CR407652 DQ297142 L19184 X67951

GenPept

AAA50464 AAH07063 AAH21683 AAV38545 ABB84465 BAG70076 BAG70202 CAA48137 CAG28580 CAI13095 CAI13096 CAI13097 EAX06975 EAX06976 EAX06978 EAX06979 EAX06980 EAX06981 EAX06982

RNA Seq Atlas

5052