InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Wnt9a

Summary

InnateDB Gene

IDBG-178561.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wnt9a

Gene Name

wingless-type MMTV integration site 9A

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000126

Encoded Proteins

IDBP-178563

wingless-type MMTV integration site 9A

IDBP-263797

wingless-type MMTV integration site 9A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143816:
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region. [provided by RefSeq, Jul 2008]
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75%% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:59306928-59333552

Strand

Forward strand

Band

B1.3

Transcripts

ENSMUST00000000128	ENSMUSP00000000128
ENSMUST00000108783	ENSMUSP00000104411

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005515	protein binding

Biological Process

GO:0007093	mitotic cell cycle checkpoint
GO:0007275	multicellular organismal development
GO:0008285	negative regulation of cell proliferation
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0032331	negative regulation of chondrocyte differentiation
GO:0035115	embryonic forelimb morphogenesis
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045165	cell fate commitment
GO:0045597	positive regulation of cell differentiation
GO:0045880	positive regulation of smoothened signaling pathway
GO:0048704	embryonic skeletal system morphogenesis
GO:0048856	anatomical structure development
GO:0060070	canonical Wnt signaling pathway
GO:0060548	negative regulation of cell death
GO:0061037	negative regulation of cartilage development