InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wnt9a

Summary

InnateDB Protein

IDBP-263797.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wnt9a

Protein Name

wingless-type MMTV integration site 9A

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104411

InnateDB Gene

IDBG-178561 (Wnt9a)

Protein Structure

UniProt Annotation

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Expressed in adult brain, lung, skeletal muscle, heart, and 17-day embryo. {ECO:0000269PubMed:11836627}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005515	protein binding

Biological Process

GO:0007093	mitotic cell cycle checkpoint
GO:0007275	multicellular organismal development
GO:0008285	negative regulation of cell proliferation
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0032331	negative regulation of chondrocyte differentiation
GO:0035115	embryonic forelimb morphogenesis
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045165	cell fate commitment
GO:0045597	positive regulation of cell differentiation
GO:0045880	positive regulation of smoothened signaling pathway
GO:0048704	embryonic skeletal system morphogenesis
GO:0048856	anatomical structure development
GO:0060070	canonical Wnt signaling pathway
GO:0060548	negative regulation of cell death
GO:0061037	negative regulation of cartilage development