InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ppib

Summary

InnateDB Gene

IDBG-178669.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppib

Gene Name

peptidylprolyl isomerase B

Synonyms

AA408962; AA553318; AI844835; Cphn-2; Cphn2; CyP-20b

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032383

Encoded Proteins

IDBP-178671

peptidylprolyl isomerase B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166794:
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:66060169-66066629

Strand

Forward strand

Band

Transcripts

ENSMUST00000034947

ENSMUSP00000034947

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	39 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0032403	protein complex binding
GO:0042277	peptide binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0006457	protein folding
GO:0040018	positive regulation of multicellular organism growth
GO:0050821	protein stabilization
GO:0060348	bone development
GO:0061077	chaperone-mediated protein folding

Cellular Component

GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005790	smooth endoplasmic reticulum
GO:0016020	membrane
GO:0032991	macromolecular complex
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome