InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppib

Summary

InnateDB Protein

IDBP-178671.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppib

Protein Name

peptidylprolyl isomerase B

Synonyms

AA408962; AA553318; AI844835; Cphn-2; Cphn2; CyP-20b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034947

InnateDB Gene

IDBG-178669 (Ppib)

Protein Structure

UniProt Annotation

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000250}. Melanosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	39 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0032403	protein complex binding
GO:0042277	peptide binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0006457	protein folding
GO:0040018	positive regulation of multicellular organism growth
GO:0050821	protein stabilization
GO:0060348	bone development
GO:0061077	chaperone-mediated protein folding

Cellular Component

GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005790	smooth endoplasmic reticulum
GO:0016020	membrane
GO:0032991	macromolecular complex
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome