Version 5.4
Mus musculus Gene: Urod
Summary
InnateDB Gene IDBG-178996.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Urod
Gene Name uroporphyrinogen decarboxylase
Synonyms AI323803; Uro-d
Species Mus musculus
Ensembl Gene ENSMUSG00000028684
Encoded Proteins
IDBP-178998
uroporphyrinogen decarboxylase
IDBP-537391
uroporphyrinogen decarboxylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126088:
This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.[provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:116989965-116994413
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000030446 ENSMUSP00000030446
ENSMUST00000134598
ENSMUST00000150370
ENSMUST00000135164
ENSMUST00000130273 ENSMUSP00000116154
ENSMUST00000123079
ENSMUST00000127635
ENSMUST00000153629
ENSMUST00000139209
ENSMUST00000139816
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004853 uroporphyrinogen decarboxylase activity
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0042168 heme metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000126088
View Gene Order
ENSBTAG00000012644
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_203298
Heme biosynthesis pathway
REACT_233360
Metabolism of porphyrins pathway
KEGG
mmu00860
Porphyrin and chlorophyll metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_9465
Heme biosynthesis pathway
REACT_9431
Metabolism of porphyrins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00860
Porphyrin and chlorophyll metabolism pathway
INOH
INOH website
Porphyrin metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.46484
RefSeq NM_009478
OMIM
CCDS CCDS18521
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca