Version 5.4
Mus musculus Protein: Urod
Summary
InnateDB Protein IDBP-178998.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Urod
Protein Name uroporphyrinogen decarboxylase
Synonyms AI323803; Uro-d;
Species Mus musculus
Ensembl Protein ENSMUSP00000030446
InnateDB Gene IDBG-178996 (Urod)
Protein Structure
UniProt Annotation
Function Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. {ECO:0000250}.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004853 uroporphyrinogen decarboxylase activity
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0042168 heme metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID MGI:98916
InterPro IPR000257 Uroporphyrinogen decarboxylase (URO-D)
IPR006361 Uroporphyrinogen decarboxylase HemE
PFAM PF01208
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P70697
PhosphoSite PhosphoSite-P70697
TrEMBL
UniProt Splice Variant
Entrez Gene 22275
UniGene Mm.46484
RefSeq NP_033504
MGI ID
MGI Symbol Urod
OMIM
CCDS CCDS18521
HPRD
IMGT
EMBL AK172426 AL671671 BC008109 U34691
GenPept AAB18294 AAH08109 BAE43002 CAM23809

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca