InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Areg

Summary

InnateDB Gene

IDBG-179096.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Areg

Gene Name

amphiregulin

Synonyms

AR; Sdgf

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029378

Encoded Proteins

IDBP-179098

amphiregulin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26243875

Il33-dependent group 2 innate lymphoid cells (ILC2s) signal via Areg-Egfr in damaged epithelia to restore epithelial barrier function and maintain tissue homeostasis.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:91139615-91148432

Strand

Forward strand

Band

Transcripts

ENSMUST00000031325

ENSMUSP00000031325

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0014009	glial cell proliferation
GO:0014070	response to organic cyclic compound
GO:0031175	neuron projection development
GO:0032355	response to estradiol
GO:0042327	positive regulation of phosphorylation
GO:0042542	response to hydrogen peroxide
GO:0043434	response to peptide hormone
GO:0045087	innate immune response (InnateDB)
GO:0045668	negative regulation of osteoblast differentiation
GO:0045740	positive regulation of DNA replication
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP
GO:0060598	dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
GO:0060744	mammary gland branching involved in thelarche
GO:0060749	mammary gland alveolus development
GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation

Cellular Component

GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

null

View Gene Order

ENSBTAG00000018134

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04012

ErbB signaling pathway pathway

INOH

INOH website

GPCR signaling pathway

PID NCI

Cross-References

SwissProt

P31955

TrEMBL

Q4FJT2

UniProt Splice Variant

Entrez Gene

11839

UniGene

Mm.8039

RefSeq

NM_009704

OMIM

CCDS

CCDS19421

HPRD

IMGT

MGI ID

MGI:88068

MGI Symbol

Areg

EMBL

AK018590 BC009138 CH466617 CT010320 D12648 L41352

GenPept

AAB00472 AAH09138 BAA02169 BAB31296 CAJ18528 EDL05295

RNA Seq Atlas

11839