Version 5.4
Bos taurus Gene: BT.28934
Summary
InnateDB Gene IDBG-643038.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.28934
Gene Name amphiregulin precursor
Synonyms AREG; AREGB
Species Bos taurus
Ensembl Gene ENSBTAG00000018134
Encoded Proteins
IDBP-695558
amphiregulin B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26243875
[Mus musculus] Il33-dependent group 2 innate lymphoid cells (ILC2s) signal via Areg-Egfr in damaged epithelia to restore epithelial barrier function and maintain tissue homeostasis.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:91126256-91138391
Strand Forward strand
Band
Transcripts
ENSBTAT00000024140 ENSBTAP00000024140
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0032355 response to estradiol
GO:0045740 positive regulation of DNA replication
GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
GO:0060744 mammary gland branching involved in thelarche
GO:0060749 mammary gland alveolus development
GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0009986 cell surface
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
null
View Gene Order
ENSMUSG00000029378
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
mmu04012
ErbB signaling pathway pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.28934
RefSeq NM_001099092 XM_005208110
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca