InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adrb1

Summary

InnateDB Gene

IDBG-179107.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adrb1

Gene Name

adrenergic receptor, beta 1

Synonyms

Adrb-1; beta-AR

Species

Mus musculus

Ensembl Gene

ENSMUSG00000035283

Encoded Proteins

IDBP-179109

adrenergic receptor, beta 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000043591:
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:56722372-56724862

Strand

Forward strand

Band

Transcripts

ENSMUST00000038949

ENSMUSP00000040847

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004940	beta1-adrenergic receptor activity
GO:0005057	receptor signaling protein activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0030165	PDZ domain binding
GO:0031694	alpha-2A adrenergic receptor binding
GO:0035240	dopamine binding
GO:0046982	protein heterodimerization activity
GO:0051379	epinephrine binding
GO:0051380	norepinephrine binding

Biological Process

GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0002024	diet induced thermogenesis
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
GO:0003061	positive regulation of the force of heart contraction by norepinephrine
GO:0003084	positive regulation of systemic arterial blood pressure
GO:0005980	glycogen catabolic process
GO:0006915	apoptotic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007266	Rho protein signal transduction
GO:0007568	aging
GO:0007613	memory
GO:0009409	response to cold
GO:0010460	positive regulation of heart rate
GO:0019233	sensory perception of pain
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031649	heat generation
GO:0032320	positive regulation of Ras GTPase activity
GO:0033365	protein localization to organelle
GO:0035811	negative regulation of urine volume
GO:0040015	negative regulation of multicellular organism growth
GO:0042060	wound healing
GO:0042596	fear response
GO:0043065	positive regulation of apoptotic process
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045986	negative regulation of smooth muscle contraction
GO:0046878	positive regulation of saliva secretion
GO:0050873	brown fat cell differentiation
GO:0051924	regulation of calcium ion transport
GO:0055088	lipid homeostasis
GO:0060080	regulation of inhibitory postsynaptic membrane potential
GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development
GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0086004	regulation of cardiac muscle cell contraction
GO:1900135	positive regulation of renin secretion into blood stream
GO:2001259	positive regulation of cation channel activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle