InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.79981

Summary

InnateDB Gene

IDBG-648826.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.79981

Gene Name

beta-1 adrenergic receptor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001242

Encoded Proteins

IDBP-701542

beta-1 adrenergic receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000043591:
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 26:34805081-34806484

Strand

Forward strand

Band

Transcripts

ENSBTAT00000001639

ENSBTAP00000001639

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004935	adrenergic receptor activity
GO:0004940	beta1-adrenergic receptor activity
GO:0005057	receptor signaling protein activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0030165	PDZ domain binding
GO:0031694	alpha-2A adrenergic receptor binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0002024	diet induced thermogenesis
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0009409	response to cold
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031649	heat generation
GO:0032320	positive regulation of Ras GTPase activity
GO:0040015	negative regulation of multicellular organism growth
GO:0042596	fear response
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045823	positive regulation of heart contraction
GO:0050873	brown fat cell differentiation
GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway