Version 5.4
Mus musculus Gene: Eif2b3
Summary
InnateDB Gene IDBG-179210.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif2b3
Gene Name eukaryotic translation initiation factor 2B, subunit 3
Synonyms 1190002P15Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000028683
Encoded Proteins
IDBP-179212
eukaryotic translation initiation factor 2B, subunit 3
IDBP-268745
eukaryotic translation initiation factor 2B, subunit 3
IDBP-268747
eukaryotic translation initiation factor 2B, subunit 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070785:
The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:117019402-117087306
Strand Forward strand
Band D1
Transcripts
ENSMUST00000070610 ENSMUSP00000070334
ENSMUST00000106448 ENSMUSP00000102056
ENSMUST00000106447 ENSMUSP00000102055
ENSMUST00000135121
ENSMUST00000151760
ENSMUST00000155181
ENSMUST00000129587
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0008135 translation factor activity, nucleic acid binding
GO:0016779 nucleotidyltransferase activity
Biological Process
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0009058 biosynthetic process
GO:0009408 response to heat
GO:0009749 response to glucose
GO:0014003 oligodendrocyte development
GO:0032057 negative regulation of translational initiation in response to stress
GO:0043087 regulation of GTPase activity
GO:0043434 response to peptide hormone
GO:0043547 positive regulation of GTPase activity
GO:0051716 cellular response to stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005851 eukaryotic translation initiation factor 2B complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000070785
View Gene Order
ENSBTAG00000019010
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03013
RNA transport pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1815
Recycling of eIF2:GDP pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001111277 NM_175135
OMIM
CCDS CCDS18524 CCDS51279
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca