Version 5.4
Mus musculus Gene: Man1a2
Summary
InnateDB Gene IDBG-179238.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Man1a2
Gene Name mannosidase, alpha, class 1A, member 2
Synonyms AI428775; AI528764; AI854422; Man1b; PCR2
Species Mus musculus
Ensembl Gene ENSMUSG00000008763
Encoded Proteins
IDBP-179240
mannosidase, alpha, class 1A, member 2
IDBP-540130
mannosidase, alpha, class 1A, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198162:
Alpha-mannosidases function at different stages of N-glycan maturation in mammalian cells. See MAN2A1 (MIM 154582) for general information.[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:100562208-100685503
Strand Reverse strand
Band F2.2
Transcripts
ENSMUST00000008907 ENSMUSP00000008907
ENSMUST00000133642
ENSMUST00000130066 ENSMUSP00000116489
ENSMUST00000123442
ENSMUST00000146818
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0007585 respiratory gaseous exchange
GO:0009100 glycoprotein metabolic process
GO:0048286 lung alveolus development
Cellular Component
GO:0000139 Golgi membrane
GO:0005730 nucleolus
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198162
View Gene Order
ENSBTAG00000003586
Not yet available
Pathways
NETPATH
REACTOME
REACT_206143
Transport to the Golgi and subsequent modification pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_237472
Asparagine N-linked glycosylation pathway
REACT_198545
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 pathway
REACT_198544
N-glycan trimming and elongation in the cis-Golgi pathway
KEGG
mmu00510
N-Glycan biosynthesis pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25396
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 pathway
REACT_25210
N-glycan trimming and elongation in the cis-Golgi pathway
REACT_25046
Transport to the Golgi and subsequent modification pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00510
N-Glycan biosynthesis pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.271617 Mm.401081
RefSeq NM_010763
OMIM
CCDS CCDS17676
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca