Version 5.4
Mus musculus Gene: Erg
Summary
InnateDB Gene IDBG-179250.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Erg
Gene Name avian erythroblastosis virus E-26 (v-ets) oncogene related
Synonyms D030036I24Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000040732
Encoded Proteins
IDBP-179252
avian erythroblastosis virus E-26 (v-ets) oncogene related
IDBP-253005
avian erythroblastosis virus E-26 (v-ets) oncogene related
IDBP-253007
avian erythroblastosis virus E-26 (v-ets) oncogene related
IDBP-400780
avian erythroblastosis virus E-26 (v-ets) oncogene related
IDBP-400781
avian erythroblastosis virus E-26 (v-ets) oncogene related
IDBP-400778
avian erythroblastosis virus E-26 (v-ets) oncogene related
IDBP-626318
avian erythroblastosis virus E-26 (v-ets) oncogene related
IDBP-707453
IDBP-706358
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157554:
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2012]
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing\'s sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:95359169-95586593
Strand Reverse strand
Band C4
Transcripts
ENSMUST00000077773 ENSMUSP00000076949
ENSMUST00000113848 ENSMUSP00000109479
ENSMUST00000113846 ENSMUSP00000109477
ENSMUST00000121809 ENSMUSP00000113723
ENSMUST00000118113 ENSMUSP00000112698
ENSMUST00000122199 ENSMUSP00000114072
ENSMUST00000171646 ENSMUSP00000132766
ENSMUST00000177450 ENSMUSP00000134930
ENSMUST00000176345 ENSMUSP00000135568
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 7 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 68 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0030154 cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000157554
View Gene Order
ENSBTAG00000011001
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
FGF8 signaling (Mouse) pathway
INOH website
FGF signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.164531
RefSeq NM_133659 XM_006522893 XM_006522894 XM_006522895 XM_006522896 XM_006522897 XM_006522898 XM_006522899 XM_006522900 XM_006522901 XM_006522902 XM_006522903 XM_006522904 XM_006523161 XM_006523162 XM_006523163 XM_006523164 XM_006523165 XM_006523166 XM_006523167 XM_006523168 XM_006523169 XM_006523170 XM_006523171 XM_006523172
OMIM
CCDS CCDS37411
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca