InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Erg

Summary

InnateDB Protein

IDBP-400778.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Erg

Protein Name

avian erythroblastosis virus E-26 (v-ets) oncogene related

Synonyms

D030036I24Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114072

InnateDB Gene

IDBG-179250 (Erg)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.

Subcellular Localization

Nucleus. Cytoplasm {ECO:0000250}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	68 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0030154	cell differentiation