InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ets2

Summary

InnateDB Gene

IDBG-179280.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ets2

Gene Name

E26 avian leukemia oncogene 2, 3' domain

Synonyms

AU022856; Ets-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022895

Encoded Proteins

IDBP-179282

E26 avian leukemia oncogene 2, 3' domain

IDBP-531599

E26 avian leukemia oncogene 2, 3' domain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157557:
This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:95702075-95721051

Strand

Forward strand

Band

Transcripts

ENSMUST00000023612	ENSMUSP00000023612
ENSMUST00000145509
ENSMUST00000143554
ENSMUST00000155226	ENSMUSP00000116638
ENSMUST00000140544

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0035259	glucocorticoid receptor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0030154	cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter